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Pharmaceutical applications Infectious agents, vaccines and therapy Characterization, a n d Induction o f Phenylalanine Ammonia-lyase Isoforms from Elicitor-treated Cell Suspension Cultures. Plant Physio11990, 92:447~i56. KERRGP, CARTERJV: Relationship Between Freezing Tolerance o f Root-Tip Ceils and Cold Stability o f Mlcrotubules in Rye (secale-Cereale L CV Puma). Plant Physio11990, 93:77-82. KHANAA~PRUSINSK]J: Kinetic Enhanced 1aminocydopropane-l-~trboxylic Acid Utilization During Alleviation o f High Temperatures Stress i n Lettuce Seeds. Plant physio11989, 91:733-737. KP,ISHNAMURTHYR, BHAGWATKA~Polyamines as Modulators o f Salt Tolerance in Rice Cultivars. Plant Physio11989, 91:500-505. LAROSAPC, SINGHNI~ HASEGAWAPM, BRESSANRA: Stable NaCI Tolerance of Tobacco Cells is Associated with Enhanced Acenmulation o f Osmotin. Plant Physio11989, 91:855-861. LOGEMANNJ, SCHELLJ: Nucleotide Sequence and Regulated Expression o f a Wound-inducible Entatn Gene ( w u n l ) . Mol Gen Genet 1989, 219:81~8. MARA~AC, GARCIA-OLMEDOF, C~qBONEROP: Differential Expression o f Two Types of Sucrose SynthaseEncoding Genes in Wheat i n Response to Anaerobiosis, Cold Shock and Light. Gene 1990, 88:167-172. OHSHIMAM, ITOHH, MATSUOKAM, MURAKAMIT, OHASHIy: Analysis o f Stress-induced or Sallcyclic Acidinduced Expression o f the Pathogenesis-related l a Protein Gene in Transgenic Tobacco. Plant Cell 1990, 2:95-106. REGGIANIR, HOCHKOEPPLERA, BERTANI& Polyamines i n Rice Seedlings Under OxYSen-deficit Stress. Plant Phys/o/1989, 91:1197-1201. SENARATNAT, MCKERSIEBD, BOWLEYSR: Desiccation Tolet-aJlce o f AIf~lf~ (Medicago Sativa L) Somatic Embryos. Influence o f Abscisic Acid, Stress Pretreatments and Drying Bates. Plant Sci 1989, 65:253. STEFFENKL, PALTAJP: Growth and Development Temperature Influences Level o f Tolerance to High Light Stress. Plant Physio11989, 91:1558-1561. TANAKAK, MACHIDAT, SUGIMOTOT: Ozone Tolerance and Glutathione Reductase i n Tobacco Cultlvars. Agric Biol G~om1990, 54:1061 1062. TEPPERMANJM, DUNSMUmP: Transformed Plants with Elevated Levels o f Chloroplastic SOD ace n o t More Resistant to Superoxide Toxicity. Plant Mol Bio11990, 14:501-512. VANCENC, COPESDO, ZAERRJB: Differences i n Proteins Synthesized i n Needles o f Unshaded and Shaded Pinus-ponderosa Vat Scopulorum Seedlings During Prolonged Drought. Plant Pbysio11990, 92:1244-1248. WERETILNYKEA, HANSONAD: Molecular Cloning of a Plant Betaine~aldehyde Debydrogenase, an

Enzyme Implicated i n Adaptation to Salinity and Drought. Proc Natl Acad Sci U S A 1990, 87:2745-2749. WINGD, KONCZC, SCHELLJ: Conserved Function i n Nicottana-tabacum o f a Single Drosophlla-hsp70 Promotor Heat Shock Element w h e n Fused to a Minimal T-DNA Promoter. Mol Gen Genet 1989, 219:9-16. ZIMMER~ANJl~ APUYAN, DARW1SHK, O'CAI~OLLC: Novel Regulation o f Heat Shock Genes During Carrot Somatic Embryo Development. Plant Cell 1989, 1:1137-1146.

Molecular biology of plant development BENFEYPN, TAKATSUJ1H, REN L, SHAHDM, CH[JA NH: Sequence Requirements o f the 5Enolpyruvylshtkimate-3-Phosphate Synthase 5'Upstream Region for Tissue-Specific Expression i n Flowers and Seedlings. Plant Cell 1990, 2:849~856. BROOTHAERTSWJ, VANLAERE& W~'ITERSR, PRRAIJX G, DEco*ckB, VANDAMMEJ, VENDINGJC: Purification and N-terminal Sequencin s of Style Glycoproteins Associated with Selfincompatibility in Petunia Hybrlda. Plant Mol Biol 1990, 14:93-102. CONKUNGMA, CHENGCI0 yAMAMOTOYT, GOODMANHM: Isolation o f Transcriptionally Regulated RootSpecific Genes from Tobacco. Plant Pbysio11990, 93:1203-1211. FENDERSE, OCONNELEM& Expression of the Heat Shock Response in a Tomato interspecific Hybrid is n o t intermediate B e t w ~ n the 2 Parental Responses. plant Physio11990 , 93:1140-1146. FENGX-H, DUBESK, BOTTINOPJ, KUNGS-D:Restoration of Shooty Morphology o f a Nontumorous Mutant Of Ntcotlana Glauca x N Langsdor:O~ by Cytoktntn and the lsopentyltransferase Gene. Plant Mol Bio11990, 15:407-420. G l ~ PM, CHUANH: Localization of a Phytochrome-Responslve Element Within the Upstream Region n f Pea RbcS-3A. Mol Cell Biol 1990, 10:5565-5568. GLOUDEMANST, BISSEL1NGT: plant Gene Expression i n Early Stases of Rb/zob/un~legume Symbiosis. Plant Sci 1989, 65:1-14. HAJELARI~ HORVATHDP, G1LMOURSJ, THOMASHOWME: Molecular Cloning and Expression o f Cot (ColdRegulated) Genes i n Arabidopsis-Thallana. Plant PbyM0/1990, 93:1246-1252. HENFREYRD, PROUDFOOTLMF,COVEYSN, SLATERRJ: Identification Control of an Inhibitor of Transcription i n Extracts Prepared from Wheat Shoot Nuclei. Plant Sci 1989, 64:91-98.

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Pharmaceutical applications Infectious agents, vaccines and therapy Related review: Vaccines (pp 215-219) AKERBOLMI~ H1NKtRAJ, BROLIDENPA, MAKITALOB, FRIDBERGERT, ROSENJ, VILIACRESERIgSSONM, MOREINB, WAHRENB: Neutralizing Cross-reactive and Nonneutralizing Monoclonal Antibodies to HIV-1 Gp120. A/DS 1990, 4:953-960. ADAGL The lmmtmologlcal Principles o f O@ Vaccination. Modern Vaccines Edited by Moxon F~ London: Edward Arnold 1990, :8-23. [4]. AGARWALRP, BUSSOME, MIANAM, RESNICKL: Uptake o f 2", 3"-dideoxyadenosine i n Human Immunedeficieney Virus-infected and Nonf l l f e ( ~ Hllman C~lls. AIDS Res Hum Retroviruses 1989, 5:541-550. AGTERBERGM, ADRIAKNSEH, BARTELINGS, VANMAANENK, TOMMA~ENJ: Protection of Guinea-Pigs Against Foot-and-Mouth Disease Virus by Immunization with a PhoE FMDV Hybrid Protein. Vaccine 1990, 8:438-440.

AGTERBERGM, ADPdAANSEH, IANIqMOFH, MELOENR, TOMMASSENJ: Outer Membrane PIloE Prote~n o f Escbetqdb~ CoH as a Carrier for Foreign Antigenic Determinants: Immunogenicity o f Epitopes of Foot-and-mouth Disease Virus. Vaccine 1990, 8:85. AGURZ: Clinical Trials of Zldovudine i n HIV Infection [letter]. Lancet 1989, ii:1400. AHMEDZU, SARKERi l ~ SACKDA: Protection o f Adult Rabbits and Monkeys for Lethal Shigellosis by Oral Immunization w i t h a T h y m i n e - r e q ~ g and Temperature-sensitive Mutant o f Sh/gel/a M Y . Vaccine 1990, 8:153-158. AKESSONp, COONEYJ, K1SHIMOTOF, BJORCKI~ Prntein-H - a Novel IgG Binding Bacterial Protein. Mol Immunol 1990, 27:523-531. ALEKANDROVAGI, MAASSABHE, KENDALAP, MEDVEDEVA TE, EGOROVAY, KLIMOVAI, COX NJ: Laboratory Properties o f Cold-adapted Influenza B Live Vaccine Strains Developed i n the US and USSR, and Their B/Ann A r b o r / I / 8 6 Cold-adapted R e ~ s o r t a n t Vaccine Candidates. Vaccine 1990, 8:61 64.

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Quality control and regulatory issues ANONYMOUS:Safety o f A n t l t h r o m b i n m Concentrate: Real or A ~ t ? Better]. B/ood 1990, 76:649-650. BERNARDJ, REVEILB, NAJMANI, L1AUTAUDROGERF, FOUCHARD M, PICARDO, CATTAN& MABONDZOA, LAVERNES, GALLO RC, ZAGURYD: Dis¢~mtnatlon Between Protective and Enhancing tllV Antibodies. Aids Res Hum Retrovtruses 1990, 6:243-250. BORCZYKAA, HARNETFN, LOMBOSM, LIORH: False-Positive Identification o f Escherichia4goll O157 b y Commercial Latex Agslu*tination Tests [letter]. Lancet 1990, 336:946-947. ELUSRW, GERETYRJ: Key Issues i n the Selection o f an Expression System for Vaccine Antigens. J Med Viro11990 , 31:54-58. FESCHAREKR, QUASTU, MAASSG, MERKIEW, SCI-IWARZS: Measles Mumps Vaccination i n the F R G - an Empirical Analysis after 14 Years of Use.2. Tulerabllity and Analysis o f Spontaneously Reported Side Effects. Vaccine 1990, 8:/446-456. GALWAYAB, HSUEHAJ~V,KEENE~I~ YAMOTOM, PAUSER BCJM, BOIMEI: invitro and Invivo Bloactivity of Recombinant Human Follicle- Stimulating Hormone and Partially Deglycosylated Variants Secreted by Transfected Eukaryotic Cell Ll~es. Endocrinolo~ 1990, 127:93-100. HAMAGUCF~M, TAKAHASmI, TAKEHARAT, TAKAMATSUJ, SAGOH: Comparison o f Recombinant Tissuetype Plasminogen Activator (rt-PA) Expressed in Mouse C127 Cells and Human Vascular plasminogen Activator (HV-PA). Bio~im Biopbys Acta 1989, 1009:143-150. HILLEMANM1~ History, Precedent, and Progress i n the Development o f Mammalian Cell Culture Systems for Preparing Vaccines - - Safety Considerations Revisited. J Meal Viro11990, 31:5-12. HOPSO~EIDERPH: Vaccines, Cells, and Nucleic Acids General Conclusions [editorial]. J M e d Virol 1990, 31:6566. IMAIN, KAWAMURA~ HIGUCH]M, OH-EDAM, ORITAT, KAWAGUCHIT, OCHIN: Physlcochemical and Biological Comlmrison o f Recombit~nt Human Erythropotetin with Human Urinary ~pniettn. J B k ~ m (Tokyo) 1990, 107:352. JUSK~CHJC, GU~ERCG: Bovine Growth Hormone: Human Food Safety Evaluation. Science 1990, 249:875-883. KLEINMI, BARTLEYTD, DAVISJM, WHITELEYDW, LUHS: Isolation and Structural characterization o f

Three lsoforms of Recombinant Consensus ~xinterferon. Arch Bicchem Biophys 1990, 276:531-537. KOMIYAMAy, PEDERSENAH, KISmLW: proteolytic Activation o f Human Factors IX and X by Recombinant

Human

Factor ~

Effects of

Calcium, PhusphoHptds and Tissue Factor. Biochemistry 1990, 29:9418-9425. KUBOTAN, ORITAT, HA~I~TORIK, OH-EDAM, OCHI N, YAMAZAKI T: Structural Characterization of Natural and Recombinant Human Granulocyte ColonystimulatIng Factors. J Bio~em (Tokyo) 1990, 107:486. LASKYL& From Virus to Vaccine --Recombinant Mammalian Cell Lines as Substrates for the Production o f Herpes Simplex v i r u s Vaccines. J M e d Viro/1990, 31:59-61. LUGOSI12Analysis o f Variables o f Plasmifi Transformation of a Bacterial Vaccine: Studies On Recombinant BCG. Vaccine 1990, 8:145-149. MOHANKK, TSOAI-F, WANGHY: Conceptual Design o f a Cellular Filter to Remove Trace Viral Contaminants i n Blood. Bz~technol Prog 1990, 6:104-113. MONDORFW, SCHARRERI: Lack o f Inhibitor to Monoclo~ml-Antibody Purified Fvlli Concentrate [letter]. Lancet 1990, 336:747. NEURATHAR, Sq~ICKN, TAYLORP, RUBINSTEINP, STEVENSCE: Search for Epitope-specific Antibody Responses to the Human Immunodeficlency Virus (HIV-1) Envelope Glycoproteins Signifying Resistance to Disease Development. AIDS Res Hum Retroviruses 1990, 6:1183-1192. RENNEISENK, LESERMANL, MATYHESE, SCHRODERHe, MULLERWEG: Inhibition o f Expression o f Human Immunodeficlency Virus-1 Invttro by Antibody-Targeted Llposomes Containing Antisens¢ RNA to the Env Region. J Biol 1990, 265:16337-16342. RINASU ETA/.: Characterization o f Recombinant Factor X'llIa Produced i n $accharomyces C ~ Biotechnology 1990, 8:549 546. SLATERPE: Perils o f Switch to Inactivated Poliovaccine [letter]. Lancet 1990, 335:1219. STEWARTGT: Safety o f Pertussis Vaccine [letter]. Lancet 1990, 335:913. STORSAETERJ, HAILANDERH, FARRINGTONCP, OLINP, MOLLBY R, MILLERE: Secondary Analyses of the Efficacy of 2 AceHular Pertussis Vaccines Evaluated in a Swedish Phase-HI Trial. Vaccine 1990, 8:457-461. TSUDAE, KAWANISH1G, UEDAM, MASUDAS, SASAKI]~ The Role of Carbohydrate in Recombinant Human Erythropoietin. EurJ Biochem 1990, 188:405-411. YONM~HLENDAtlLKE: Side-effects o f Measles-mumps Vaccination [letter]. Lancet 1990, 335:540. ZUCKE?~ANAJ: Vaccines, Cells, and Nucleic Acids - Workshop o n Vaccines Prepared in Continuous Mammalian Cell Lines and by Recombinant Systems [editorial]. J Med Viro11990, 31:1 Z U C K E ~ AJ, DEE~IA~TF: VaccInes, Cells, and Nucleic Acids - - Conclusions (Reprinted) [editorial]. J Med Viro11990, 31:2-4.

Production---purification and expression systems AFFHOLTERJ ~ CASC1ERIMA, BAYNENIL,BRANGEJ, CASARETTO M, RUTHR~ Identification of Residues i n the Insulin Molecule Important for Binding to Insulin-Degrading Enzyme. Bt~hem/stry 1990, 29:7727-7733. ANICETHV~ KEYTBA, HANco*ckWS: Purity Analysis o f Protein Pharmaceuticals produced by Recombinant DNA Technology. Trends Biotedmol 1989, 7:342~348. ARATANSPIRES, SCHARFMANNR, LECI4ANRM, TASHJ1ANAHJP~ ProTRH-gene Expression by Fetal Pancreatic Islets in culture. Bioc)~m Biopbys Res Commun 1990, 168:952 958. ATODAH, MOR1TAT: A Novel Blood Coagulation Factor IX/factur X-binding Protein with Anticoagulant Activity from the Venom o f Trlmeresurus F/avov/r/d/s (Habu Snake): Isolation and characterization. J Btochem 1989, 106:808 BENDERE, KOLLERKP, ENGELSJ'~/: Secretory Synthesis of Human Interleukin-2 by Streptomyces Llvidan& Gene 1990, 86:227 232. BOYOTP, PILLETL, DUCANCELF, BOULAINJC, TREMEAUO, MENEZA: A Recombinant snake Neurotoxin Generated by Chemical Cleavage o f a Hybrid Protein Recovers Full Biological Properties. Febs Left 1990, 266:87--90.

BROWNCS, SALIMANSMMM,NOTEBORNMHM,WEILANDHT: Antigenic Parvovfrus B19 Coat Proteins VP1 and VIr2 Produced i n Large Quantities In a Baculovirus Expression System. Virus Res 1990, 15:197-211. CABILLYS: Gro'~rlth at Sub-optimal Temperatures Allows the Production o f INincttonal, Antigenb i n d i n g Fab Fragments i n ~ Colt. Gene 1989, 85:553-557. CHALETI~ FROMTLINGR~ GARRITYGM, MONAGHAN]~ HENSENSOD, VALIANTME, ZINKDL L-681,572 - - a N e w Antifungal Agent. Isolation, Characterization, and Biological Activity. J Antibiot (Tokyo) 1989, 42:171~1721. CHATERKF: The Improving Prospects for Yield Increase b y Genetic Engineering In Antibioticproducing Streptomycetes. Bioteclmology 1990, 8:115-121. CHAUDHAJ~VK~BATRAJK, GALLOMG, WIILINGHAMMC, FI~GERAIDDJ, PASTANI: A Rapid Method o f Cloning Functional Variable-region Antibody Genes i n Escherichla-coll as Single-chain Immunotuxlns. proc NatlAcad Sci U S A 1990, 87:1066-1070. CHENGYSE, MCGOWANMH, KETYNERC~ SCHLOSSJV, EmCKSONVIITANENS, YIN FH: High-level Synthesis o f R e c o m b h ~ n t HIV-1 proteuse and the Recovery o f Active Falzyme from Inclusion Bodies. Gene 1990, 87:243-2~. CONDRAJH, SARDANAW, TOMASSINIJE, SCHLABACHAJ, DAVIES M-E, IJNEBERGERDW, GRAHAMDJ, GOTt~ I~ COLONNO RJ: Bacterial Expression o f Antibody Fragments that Block Human Rhinovirus Infection of Cultured Cells. J Biol O~em 1990, 265:2292-2295. CURLESSC, POPEJ, TS~ L: Effect o f Preinduction Specific Growth Rate o n Recombinant Alpha Consensus Interferon Synthesis i n Escher/ch/a COIL Biotechnol Prog 1990, 6:149-152. CURRYK~ YEMAW, DEmELMRJR, HATZENBUHLERNT, HOOGERHEIDEJG, TOMICHCSC: Coil Expression and processing o f Human interieukln-l~ Fused to Signal Peptides. DNA 1990, 9:167-175. DANLEYDE, GEOGHEGANKF, SCHEIDKG, LEE SE, MERSON JR, FIAWRYL~SJ, RIC~mT£GA, AMMIRATIMJ, HOBART PM: Crystallizable HlV-1 protease Derived from Expression o f the Viral p o i Gene i n Colt Biochem Biophys Re$ Commun 1989, 165:1043-1050. DAUMYGO, MERENDAJM, MCCOLLAS, ANDREWSGC, FF~NKE AE, GEC~HEGANKF, OTYEI~E$SIG: Isolation and Characterization of Biologically Active Murine Interieukin-lu Derived from Expression o f a Synthetic Gene i n Escher/ch/a Colt Bioc~'m Biophys Acta 1989, 998:32-42. DESPR~SP, RU]Z-LE'~S,% CAHOURA, GmARDM, WYCHOWSm C, BOULOYM: The 15 Amino Acid Residues preceding the Amino Terminus o f the Envelope Protein i n the Yellow Fever Virus Pulyprotein Precursor Act as a Signal Peptide. ~rus Res 1990, 16:59-76. DOULLJI~ VININGLC: Nutritional Control o f Actinorhodin Production by Streptomyce~ coel/co/or A3(2) - - Suppressive Effects o f Nitrogen and Phosphate. ~1Microbtol Biotechnol 1990, 32:449-454. EIMSRW, GERETYRJ: Key Issues i n the Selection of an Expression System for Vaccine Antigens. J Med Hro/1990, 31:5~58. FISHBIENDR, DREESENDW, HOMESDE, PACERRE, LEYAB, YAGERP?~ SUMNERJW, REIDSANDENFL, SANDERLINDW, TONGTC, KEMPDT: Human Diploid Cell Rabies Vaccine Purified by Zonal CenteLfugation: a Controlled Study of Antibody Reponse and Side Effects Following Primary and Booster Preexposure Immunizations. Vaccine 1989, 7:437-442. FRANKEAE, DANLEYDE, KACZMAREKFS, HAWRYLIKSJ, GERARD RD, LEESE, GEOGHEGANKF: Expression o f Human Plasminogen Activator I n h i b i t o r Type-1 (pAL 1) i n Escher/ch/a Colias a Soluble Protein Comprised o f Active and Latent Forms. Isolation and Crystallization of Latent PALL Bio~im Bi~,ysActa 1990, 1037:16-23. FUH G, MUIJ~RRINMG, BASSS, MCFARLANDN, BROCHIER M, BOURELLJH, LIGHTDR, WELLSJA: The Human Growth Hormone Receptor. Secretion from Es~berichta Coliand Disulfide Bonding Pattern of the Extracellular Binding Domain. J Biol Chem 1990, 265:3111-3115. FUJIWARAS, IMAIJ, FUJIWARAM, YAESH1MAT, KAWASHIMAT, KOBAYASHIK: A Potent Antibacterial Protein i n Royal Jelly - - Purification and Determination o f the Primary Strucmre of Royaltsin. J Biol Goem 1990, 265:11333-11337. FUNAYAMAS, ISH~ASHIM, ~ Y, MIYAUCVaM, MORIH, KOMIYAMAK, OMURAS: Novel Cytocidal Antibiotics,

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that Bind to a Common Insulin Gene Sequence. MOl Cell Biol 1990, 10:1564-1572.

Allergy and inflammation ACARREGUIMJ, SNYDERJM, MITCHELLMD, MENDELSONCPc Prostaglandtns Regulate Surfactant Protein-A (Sp-A) Gene Expression i n H u m a n Fetal Lung invitro. Endocrinology 1990, 127:1105-1113. BAILYH: Research Paper Analysis - - can Antibodies to IgE Act as Anti-allergics. B i o t ~ l o g y 1990, 8:96. BANERJEERK: Nonsteroidal Anti-Inflammatory Dt~lgs I n h ib it Gastric Peroxtdase Activity. Biochim BiotThysActa 1990, 1034:27~280. BARmiAMM: Hypeesensltivity a n d Streptokinase [letter]. Lancet 1990, 335:535. BAUMANNH, GAULDIEJ: Regulation of Hepatic Acute Phase Plasma Pr o te in Genes by Hepatocyte Stimulating Factors a n d O t h e r Mediators of Inflammation. MOl Biol Med 1990, 7:147 159. CAMUSSIG, TETTAC, BUSSOLINOF, BAGUONIC: Antilnflamq0tatOry Peptides (aOtiflamminS) I n h ib it Synthesis of Piatelet-activating Factor, N e u t r o p h i l Aggregation and Chemotaxts, and I n t r a d e r m a l Inflammatory Reactions. J Exp Med 1990,171:913~928. CAMUSSIG, TETTAC, BUSSOLINOF, METAFORAS, PELUSO G, ESPOSITOC, PORTAPc An Anti-Inflammatory Protein Secreted f r o m th e Rat Seminal Vesicle Epithelium Inhibits t h e Synthesis o f PlateletActivating Factor a n d t h e Release o f Arachidonic Acid a n d Prostacyclin. Eur J Biochem 1990, 192:481-485. CHANGTW, DAVISFM, SUN NC, SUN CRY, MACGLASHANDW, HAMILTONRG: Monoclonal Antibodies Specific for H u m a n IgE-producing B Cells - - a Potential Therapeutic for IgE-medlated Allergic Diseases. Biotechnology 1990, 8:122-126. CHRETIENI, PENEJ, BRmREF, MALEHJTRD, ROUSSETF, DEVRmSJE: Regulation o f H u m a n IgE Synthesis.1. Human IgE Synthesis Invitro is D e t e r m i n e d by the Reciprocal Antagonistic Effects o f Interleukin-4 a n d Interferon-oamma~ EurJ lmmunol 1990, 20:243-251. COLUMBOM, GALEONED, GUEDIG, KAGEY-SOBOTKA~ LICHTENSTEINLM, PETITrGR, MARONEG: Modulation of Mediator Release f r o m H u m a n Basophlls and Pu lm o n a r y Mast Ceils and Macrophages by Auranofin. B i ~ Pharmaco11990, 39:28~292. DAHINDENCA, KURIMOTOY, DE WECKAL, LINDLEYI, DEVALD B, BAGGIOL~ M: The Neutropifil-activating PepUde NAF/NAP-1 Induces Histamine a n d Leukotriene Release by I n t e r l e u k i n 3-primed Basophlls. J Exp Med 1989, 170:1787. DEJOYSQ, FERGUSONCHANOWITZ[~ ORONSKYAI~ ZABRISKIE JB, KERWARSS: Studies o n t h e H o m i n g o f Mycobacterinm-Sensitized Lymphocytes- T to th e Synovinm D u r i n g Passive Adjuvant Arthritis. Cell lmmuno11990, 130:195-203. DENZUNGERC, KAPPA, GRIMBERGM, GERHARTZHH, WILMANNSW: Enhanced Endogenous Leukotriene Biosynthesis i n Patients Treated w i t h Granulocyt e-macrophage Clonoy-stimuiating Factor. Blood 1990, 76:1765-1770. DESMOULINSD, PONTEZIEREC, AGNERAYJ, EKENDJIAN0(3, CAIS MJ: Effects of H u m a n Recombinant ILlBeta o n Rheumatoid a n d Non- Rheumatoid H n m a n Synovtal Cell Growth. Cell Mol Biol 1990, 36:309~316. FmESTE~NGS, ALVARO-GARCIAJM, MArePc Quantitative Analysis o f Cytokine Gene Expression in Rheumatoid Arthritis. J lmmunol 1990, 144:3347-3353. f*ckUOKAY, HUGHTE: Anaphylatoxin Binding a n d Degradation by Rat Peritoneal Mast Cells Mechanisms o f D e g r a n u la tio n a n d Control. f Immuno11990, 145:1851 1858. GILESH: More Selective H g a n d s at Elcosanoid Receptor Subtypes Improve Prospects i n Inflammatory a n d Cardiovascular Research. Trends Pharmacol Sci 1990, 11:301-304. GODFREYHP: T-Cell Ftbronectin - a n Unexpected Inflammatory Lymphokine. Lymphokine Res 1990, 9:435-447. HORROBINDF, STEWARTC: Evening Primrose Oil a n d Atoplc Eczema [letter]. Lancet 1990, 336:50. HOWELLMD, W~rLERSST, OLEET, POWELLHC, CARLODJ, BEOSTOFFS~V:Vaccination Ao-ain.t Experimental Allergic Encephalomyelitis w i t h T Ceil Receptor Peptides. Scieme 1989, 246:668~69. JACQUEMINMG ETAL: Successful T r e a t m e n t o f Atopic Dermatitis w i t h Complexes o f Allergen a n d Specific Antibodies [letter]. Lancet 1990, 335:1468. JONATC, RAHMSDORFHJ, PARKKK, CATOACB, GEBELS, PONTAH, HERRI2CHP: A n titu m o r P r o m o t i o n a n d

347

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Blood

- Miscellaneous

Antiinflammation- Down-Modulation o f Ap-1 (Fos Jtm) Activity by Glucocorticnid Hormone. Cell 1990, 62:1189-1204. KANDAY, YAMAMOTON, YOSH1NOY: utilization o f Vitamin-A i n Rats with Inflammation. Biochim BiophysActa 1990, 1034:337-341. LOMBARDEROM, HEYMANNPW, PLATPS-MILLSTAE, FOX JW, CHAPMANMD: Conformatlonal Stability o f B Cell Epitopes o n Group I and Group l I / k , rmatophago/des Spp. Allergens: Effect of Thermal and Chemical Denaturation on the Binding o f Murine ISG and Human IgE Antibodies. J Immuno11990, 144:1353-1360. MACNAULK~ C ~ N, LARKM, TOCCIMJ, HUTCHINSON NI: Dlscoordinate Expression of Stromelysin, Collagenase, and Tissue Inhibitor o f Metalloproteinases-1 i n Rheumatoid Human Synovial Flbroblasts - Synergistic Effects o f Interleukin-1 and Tumor Necrosis Factor-Alpha on Stromelystn Expression. J Biol Chem 1990, 265:17238-17245. MARQUARDTDL, WALKERIL: Modulation of Mast Cell Responses to Adenosine by Agents that Alter Protein ~ - C Activity. Biochem Pharmaco11990, 39:1929-1934. MEIB1CKLM, TURNERBG, PUMAP, PRICE-TILIDTSONB, SALVATOKA~DUMA1SDR, Morn DT, BROEZERJ, AVGERINOS GC: Characterization o f a Nonglycusylated Single Chain Urinary Plasminogen Activator Secreted from Yeast. JBiol Chem 1990, 265:801~807. MUDDEGC, VANREIJSENFC, BOIANDGJ, DEGASTGC, BRUIJNZEELPLB, ]~RUIJNZEELKOOMENCAFM:Allergen Presentation by Epidermal Iangerhans Cells from Patients with Atoplc Dermatitis is Mediated by lgE. Immunology 1990, 69:335-341. PFEILSCHII~ERJ, MUHLH: Interleukln-1 and Tumor Necrosis Factor Potentiate Anglotensin-IIStimulated, and Calcium Ionophore-Stimulated Prostaglandin E2 Synthesis i n Rat Renal Mesanglal Ceils. Biochem Biophys Res Commun 1990, 169:585-595. PRESCOTTSi, SEEGERAP~Z1MMERMANGA, MCINTYRETM, MARAGANOREJM: Hlrudin-Ba~d Peptides Block the Inflammatory Effects o f ThrombIn o n Endothelial Cells. J Biol (~E~m1990, 265:9614-9616. RAVELP, KRAUSJL, LEDERERF: Pol~eA'tc Analogues o f N-Formyl Peptldes ace Potent Activators o f Degranulatinn and Superoxide Production by Human Neutrophtls. Biochem Biophys Res Commun 1990, 171:266~272. REMMERSEF, LAFYATISR, KUMKUMIANGK, CASEJP, ROBERTS AB, Sp*rnMB, WILDERRI: Cytoklnes and Growth Regulation of Synoviocytes from Patients with Rheumatoid Arthritis and Rats w i t h Streptococcal Cell Wall Arthritis. Growth Fact 1990, 2:179-188. ROMAGNAN1S: Regulation and Deregulation o f Human lgE Synthesis [Review]. Immunol Today 1990, 11:316-321. SECKINGERP, VEY E, TURCATTIG, WINGFIELDP, DAYER JM: Tumor Necrosis Factor Inhibitor - Purification, NH2-Termlnal Amino Acid Sequence and Evidence for Anti-lnflammatory and l m m t m o m o d u l a t o r y Activities. EurJ Immunol 1990, 20:1167-1174. STEFAN1DV, VELTISHCHEVYE, SEMYONOVAT, KUDRINAGP: Suppression of Auaphylactic Shock i n Sensitized Guinea Pigs by CytochalasIn B. lmmunol Lett 1989, 22:193-194. SURFICD, COPPELP-, GERSHWINME: Structural Requirement for Autoreactivity o n Human Pyruvate Dehydrogenase-E2, the Major Autoanflgen of Primary Bifiacy cirrhosis - Implication for a Conf~rmatinnal Autoepitope. J lmmuno11990, 144:3367-3374. TEPPERRI, LEVINSONDA, STANGERUZ, CAMPOSTORRESJ, ABBASAK, LEDERP: ll-4 Induces Allergic-Like Inflammatory Disease and Alters T- Cell Development i n Transgenic Mice. Cell 1990, 62:457~t67. TOVEYER, JOHNSONMC, ROCHEAI~ COBONGS, BALDOBH Cloning and Sequencing o f a CDNA Expressing a recombinant House Dust Mite Protein that Binds Human IgE and Corresponds to an Important Low Molecular Weight Allergen. J Exp Med 1989, 170:1457-1462. TWOMEYB, MU1DRE, NIXONJS, SEDGWICKAD, WILKINSON SE, DALEMM: The Effect o f New Potent Selective Inhibitors o f Protein Klnase-C ou the Neutrophil Respiratory Burst. B'~chem Biophys Res Commun 1990, 171:1087 1092. UETRECHTJ: Mechanism o f Hypersensitivity Reactions: Proposed Involvement o f Reactive Metabolites

Generated by Activated Leukocytes. Trends Pharmacol Sci 1989, 10:463. UME~aS: Effects of Non-steriodal Anti-inllalnlmttory Drugs o n Huamn Neutrophll NADPH Oxidase i n Both Whole Cell and Cell-free Systems. Blochem Pharmaco11990, 40:559-564. VISHERCA. DOUGALLWC, WilSONJM, BURRIA, NICKHS: Regulation o f Manganese Superoxide Dismutase by Llpopolysacchartde, Interlenkin-1, and Tumor Necrosis Factor - - Role i n the Acute Inflammatory Response. J Biol Chem 1990, 265:2856~2864. WAAGEA, HALSTENSENA, SHAIABYR, BRANDTZAEGp, KIERULF P, ESPEVlKT: Local Production of Tumor Necrosis Factor ct, Interleukin 1, and Interleukln 6 in Meningococcal Meningitis. Relation to the Inflammatory Response. J Exp Med 1989, 170:1859-1868. WAHLSM, ALLENJB, WONGHI, DOUGHERTYSF, ELLINGSWORTH LPCAntagonistic and Agontstie Effects o f Transforming Growth Factor-Beta and il1 i n Rheumatoid Synovium. J Immuno11990, 145:2514--2519. WHITEJ1L ZEMBRYKID, HANNAN, MONGS: Differential I n h i b i t i o n of Histamine Release from Mast Cells bY Protein Klna~-C lnhibttors - Staurosporine and K-252A. Biochem Pharma6o11990, 40:447 456. WIERENGA~ SNOEKM, l~OSJD, JANSENHM, KAPSENBERGML: Comparison of Diversity and Function o f House Dust Mite- Specific Lymphocyte-T Clones from Atopie and Non-Atopic Donors. EurJ Immunol 1990, 20:1519-1526. YAMADAM, ZURBPdGGEN& FUJINA2~RS: Monoclonal Antibody to Thellers Murine Encephalomyelitis Virus Defines a Determinant o n Myelin and oligodendrocytes, and Augments Demyelination i n Experimental Allergic Encephalomyelitis. J Exp Med 1990, 171:1893-1907. yAM~YOSI~M, OHUEM, KAWASVmvtAH, KOTAN1H, I~A M, KAWATAS, YAMADAM: A Human H-l-Alpha Derivative Which Lacks Prostaglandin-E2 Inducing Activity and Inhibits the Activity of 11-1 Through Receptor Competition. Lymphokine Res 1990, 9:405-413. ZHANGZYJ, LEECSY, LIDERO, WEINERHI~ Suppression o f Adjuvant Arthritis in Lewis Rats by Oral Administration of Type-lI Collagen. J Immunol 1990, 145:248~2493.

Blood ANONYMOUS:Safety of A n t i t h r o m b i n HI Concentrate: Real o r Apparent? [letter]. Blood 1990, 76:649-650. BISHOP PD, LASSERGW, LETRONGI, STENKAMPRE, TELLER DC: Human Recombinant Factor-XIII from Saccharomyces-Cerevisiae - Crystallization and Preliminary X-Ray Dam. JBiol Chem 1990, 265:1388~13889. BLAKELEYD, TOLLIDAYB, COLACOC, ROSERB: Dry IBstant Blood Typing Plate for Bedside Use. Lancet 1990, 336:854~55. COLOMBOM ETAL:Specificity o f Hepatitis C Antibody ELISA i n Patients with HaemophUia [letter]. Lancet 1990, 335:1345. CROSSLEYM, BROWNLEEGG: Disruption of a C/EBP Binding Site i n the Factor IX Promoter is Associated with llaemophllia B [letter]. Nature 1990, 345:444--446. DANKOJ ETA/_:Epoetin Alfa for Postpartum Anaemia [letter]. Lancet 1990, 335:737. FISCHLMETAL: Recombinant Human Erythroprotein for Patients with AIDS Treated with Zidovudine. N EnglJMed 1990, 322:1488-1493. GRIFFINCG, GP,ANTBW: Effects o f Recombinant Interferons on Human Megakaryocyte Growth. Exp Hemato11990, 18:1013-1018. GUINANEC, SIEFFCA, OETTEDH, NATHANDG: A Phase I/I1 Trial Recombinant Granulocyte-macrophage Clony-stimulating Factor for c h i l d r e n with Aplastir Anemia. Blood 1990, 76:1077-1082. HUNTBJ ETAL: I n h i b i t i o n by Aprotinin of TPAmediated Fibrtnolysts During Orthotopic Liver Transplantation [letter]. Lancet 1990, 336:381. KANEWH, DEVORECARTERD, ORTELTL Expression and Characterization o f Recombinant Human Factor-V and a Mutant Lacking a Major Portion o f the Connecting Region. Bt0chem~try 1990, 29:6762-6768. LALEZARII, LALEZARIP, POYARTC, MARDENM, KISTERJ, BOHNB, FERMIG, PERUTZMF: New Effectors o f Human Hemoglobin - - Structure and Function. Biochemistry 1990, 29:1515-1523.

LOSHERJM: Lack o f Inhibitor to Monoclonal-antifiody Purified Factor VIII Concentrate [letter]. Lancet 1990, 336:1249. MCMAHONFG, VARGASR, RYANM, JAINAK, ABELSRI, PERRy B, SMITHII~ Pharmaco*kinetics and Effects of Recombinant Human Erythropoietin after Intravenous and Subcutaneous Injections i n Healtyh Volunteers. Blood 1990, 76:1718-1722. MIGIJACCIOG, MIGLIACCIOAR, ADAMSONjl~: The Biology of Hematopoletic Growth Factors - Studies Invitro Under Serum-Deprived Conditions [Review]. Exp Hemato11990, 18:1049-1055. MILLERBA, OLIVlEmN, HOPE SM, FALTERDV, PERRINE SP: Interferon-Gamm,'t Modulates Fetal Hemoglobin Synthesis i n Sickle Cell Anemia and Thah~seraia. J Interferon Res 1990, 10:357-366. MONDORFW, SCHARRERI: Lack o f Inhibitor to Monoclonal-Antibody Purified Fviti Concentrate ~etter]. Lancet 1990, 336:747. MONKM, HOLDINGC: Amplification o f a ~-haemoglobin Sequence i n Individual Human Ooeytes and Polar Bodies. Lamer 1990, 335:985-987. OLDJM, VARAWALLANY, WEA13HERALLDJ: Rapid Detection and Prenatal Diagnosis of ~-thalassaemia: studies i n Indian and Cypriot Populations i n the UK. Lancet 1990, 336:834-836. PAUKOVITSWR, HERGLA, SCHULTEHERMANNPc Hemoregulatory Peptide Pglu-Glu-AsP-CysLys - a New Synthetic Derivative for Avoiding Dlmertzatinn and Loss of Inhibitory Activity. Mol Pharmaco11990, 38:401-409. POJDAZ, TSUBOIH Invivo Effects of Human Recombinant Interleukin-6 o n Hemopoiette Stem and Progenitor Cells and Circulating Blood Cells in Normal Mice. Exp Hemato11990, 18:1034-1037. SAMUELRE, SALMONED, BRIEHLRW: Nucleation and Growth o f Fibres and Gel Formation in Sickle Cell Haemoglobin [letter]. Nature 1990, 345:833835. SH]MTZKYM, SKORN~CKY: Suppression o f HIV Antigenaemia by AL721 [letter]. Lancet 1990, 335:1281. SILBERSTEINDS, DAVIDJR, HARND?c The Ability of Mouse Monoclonal Antibodies to Direct the Cytotoxic Function o f Cytoklne-Activated Human Eosinophlls. Hybr&~ma 1990, 9:237 242. SIMPSONRJ, REIDGE, MORITZRI~ MORTONC, NORTONRS: Complete Amino Acid Sequence of TenebrosinC, a Cardiac Stimulatory and ILaemolytic Protein from the Sea Anemone Actinia-Tenebrosa. EurJ Biochem 1990, 190:319~328. TANIKAWAS, NOSEM, AOIOY, TSUNEOKAK, SHIKITAM, NARA N: Effects of Recombinant Human Granniocyte Coinny-stimulating Factor o n the Hematologic Recovery and Survival o f Irradiated Mice. Blood 1990, 76:445-449. THOMSONA, COIW~RERASM, GOmCKB, KUMPELB, CHAPMAN GE, LANERS, TEESDALEP, HUGHES-JONESNC, MOLHSON PL: Clearance o f Rh D-positive Red Coils w i t h Monoclonal Anti-D. Lancet 1990, 336:1147-1149. VANDER POLLT, BI3LLERHP~ TEN CATEH, WORTELCH, BAUERKA, VANDEVENTERSJH, HACKCE, SAUERWEIN HP, ROSENBERGRD, TEN CATEJ~V:Activation o f Coagulation after Administration o f Tumor Necrosis Factor to Normal Subjects. N EnglJ Meal 1990, 322:1622-1626. WINS~ PPc Haemophllla B Caused by Mutation o f a Potential Thrombin Cleavage Site i n Factor IX. Nucleic Acids Res 1990, 18:1310. ZACHflEP ETAL: Erythropoietin, Alumininm, and Anaemia In Patients on Haemodialysis [letter]. LanCet 1990, 335:1038. ZBOINSKAE, SZTAJERH, LEJCZAKB, KAFARSIOp: Antibacterial Activity of Phosphono Dipeptides Based o n 1Amtno-l-Methylethanephosphmttc Acid. FEMS Microbiol Lett 1990, 70:23-28.

Miscellaneous AWONIY1CA, SPRANDORL, SANTULLIR, CHANDI~SHEKAR V, EWINGL[~ ~ BPc Restoration o f Spermatogeuesis by Exogenously Administered Testosterone in Rats Made Azoospermic by Hypophysectomy or withdrawal o f Luteinizlng Hormone Alone. Endocrinology 1990, 127:177-184. BALBONIG, MARASTON1M, PICONED, SALVADORIS, TANCREDI T, TEMUSBIPA, TOMATISPc New Features of the Delta-Opinid Receptor - - Conformational Properties o f Deltorphin-I Analogues. B/0chem Biophys Res Commun 1990, 169:617-622. BALLED ETAL: Autologous Bone Marrow Transplantation for Acute Myelnid Leukemia Using Monoclonal Antibody-put,ged Bone Marrow. B/ood 1990, 75:1199-1206.

Pharmaceutical applications Miscellaneous BANDARAG, LIN CW, GEORGESCUHI, MENDELOWD, EVANS CH: Chondrocyte Activation by Interleukin1: Analysis of t h e Synergistic Properties of Fibroblast Growth Factor a nd Phorbol Myristate Acetate. Arch B/0chem B/ophys 1989, 274:539 BIGBYTD, LEE DM, MESLmRN, GROENERTDC: Leukotriene A4 Hydrolase Activity o f Human Airway Epithelial Cells. B i ~ e m Biophys Res Commun 1989, 164:1-7. BUTIlm~ & SANTUCCIM& GALERP, PEROCCOP, TURAS: GM-CSF i n c u b a t i o n P r i o r to T r e a t m e n t w i t h Cytaraiflne o r D o x o r u b i c i n Enhances D r u g Activity Aoain~t AML Ceils Invitro - a Model for Leukemia Chemotherapy. Leuk Res 1990, 14:743-749. BUZONIGATELD, BERNARDF, ANDERSEN& RODOIA1GSA: Protective Effect o f Polyclonal a nd Monoclonal Antibodies Against Abortion i n Mice Infected by Chlamydla-Psittaci. Vaccine 1990, 8:343-346. COLUMBOM, GALEONED, GU~DIG, KAGEY-SOBOTKA& LICHTENSTEINLM, pETITFGR, MARONEG: Modulation of Mediator Release from Human Basophils and P u l m o n a r y Mast Cells a nd Macrophages by Auranofin. Biochem Pharmaco11990, 39:285-292. DHIVERC, OLIVED, ROUSSEAUS, TAMALETC, LOPEZM, GAIJNDOJ-P~ MOURENSM, HIRNH, GASTAUTJ-& MAWAS C: pilot Phase I Study Using g i d o v u d i n e i n Association w i t h a lO-day Course o f Anti-CD4 Monoclonal Antibody i n Seven AIDS Patients. A/ds 1989, 3:835-842. DILLERI, KASSELJ, NELSONCE, GRYKAM& LITWAKG, GEBHARDTM, BRESSACB, OZTURKM, BAKERSJ, VOGELSTEINB, FRIENDSH: P53 Functions as a Cell Cycle Control P r o t e i n in Osteosarcomas. Mol Cell B/o/1990, 10:5772-5781. EVANSDB, BUNN1NGRAD, RUSSELLRGG: The Effects o f Recombinant H u m a n i n t e r l e u k i n - l - b e t a o n Cellular P r o l i f e r a t i o n and the P r o d u c t i o n o f pgotBtaol~nd[n.E2, Plasminogen Activator, Osteocalcin and Alkaline Phosphatase by Osteoblast-like Cells Derived from H u m a n Bone. Biochem Biophys Res Commun 1990, 166:208-216. FOH G, MULKERRINbiG, BASSS, MCFARLANDN, BROCI-flER M, BOURELLJH, LIGHTDR, WELLSJA: The Huma n Growth H o r m o n e Receptor. Secretion from Est~erichia Coli a n d Disulfide Bonding Pattern of t h e E xtracellular Binding Domain. J B/o/Chem 1990, 265:3111-3115. GEORGE-NASCIMENTOC, LOWENSONJ, BORISSENKOM, CALDERONM, MEDINASELBY& KUOJ, CLARKES, RANI~LPH A: Replacement o f a Labile Aspartyl Residue l n c r e ~ e s t h e Stability of Huma n Epidermal Growth Factor. Blochem~try 1990, 29:9584-9590. GIEMBYCZM& DIAMONDJ: Evaluation of Kemptide, a Synthetic Serine-containing Heptapeptide, as a Phosphate Acceptor for the Estimation of Cyclic AMP-dependent Protein Ktnase Activity in Respiratory Tissues. Biochem Pharmaco11990, 39:271-284. GILLD: Growth H o r m o n e for Short C h i l d r e n [letter]. Lancet 1990, 335:1225. GOLDSTONEAH, KHWAJA& T he Role o f Haemopoietic Growth Factors i n Bone Marrow Transplantation. Leuk Res 1990, 14:721-729. GROSSG, WAKST, ESHHARZ: Expression o f Immunoglobulin-T-cell Receptor Chimeric Molecules as Functional Receptors w i t h Antibody-type Specificity. Proc Natl Acad Sci U S A 1989, 86:10024-10028. HAMY~ESM, GILLISJM, P1NKSTONp, ROSERb~ Effect of Zldovudtne and Granuiocyte-macrophage Colony-stimulating Factor on Huma n Immunodeficiency Virus Replication i n Alveolar Macrophages. Blood 1990, 75:121~1219. HARTMK, PALLOR~ , MATITIEWSTJ, LANGtOISAJ, LERCHE NW, MAm~ ME, SCEARCERM, MCDANALC, BOLOGNESl DP, HAYNESBF: Synthetic Peptides Containin S T-Cell and B-Celi Epitopes from Human l m m t m o d e l i c i e n c y Virus Envelope Gpl20 i n d u c e Anti-lilY Proliferative Responses a nd High Titers o f N e u t r a l i z i n g / m t i b o d i e s i n Rhesus Monkeys. J Immuno11990, 145:2677-2685. HASTHORPES, ROGERSONJ, GREENSI~ RADLEYJM: Use o f Bone Marrow Somatic Cell Hybrid Lines to Generate Monoclonal Antibodies Specifically Reactive w i t h Rare Marrow Cells. Exp Hematol 1990, 18:223-227. HATTORIN, SHIMATSUA, SUGITAM, KUMAGMS, IMURA H: l m m t m o r e a c t i v e Growth Hor mone (GH) Secretion by H uma n Lymphocytes - -

Auglnented Relt~ts¢ by Exogenous GH. BiodJem Biophys Res Commun 1990, 168:396401. HELLSTROME, ROBERTKH, SOPPIE, OST ~ pUTKONEN PO, GAHRTONG: Effects o f Retinotc Acid, 1,25d i h y d r o x y v i t a m i n D3, Cytosine Arabinoside and ~-interferon o n Bone Marrow Cells from Patients w i t h Myelodysplastic Symlromes. Leuk Res 1989, 13:1113-1122. HINO M, IWA~ M, OKAMOTOM, YOSHIDAI~ HARUTA H, OKUHARAM, HOSODAJ, KOHSAKAM, AOKIH, H: FK409, a novel Vasodllator Isolated from t h e Acid-treated F e r m e n t a t i o n Br o th of Streptomyces G ~ I.Taxonomy, Fermentation, Isolation, a n d Physico-chemical and Biological Characteristics. JAnt~biot (Tokyo) 1989, 42:1578-1583. HORI T, YAMANAKAY, HAYAKAWAM, SHIBAMOTOS, OKU N, ITO F: Growth I n h i b i t i o n of H u m a n Flbroblasts by Epidermal G r o w t h Factor i n t h e Presence of Arachidonic Acid. Biochem Biop~ys Res Commun 1990, 169:959-965. HOWELLMD, WINTERSST, OLEET, pOWELLHC, CARLODJ, BROSTOFFSW: Vaccination Against E x p e r i m e n t a l Allergic Encephalomyelitis w i t h T Cell Receptor Peptides. Science 1989, 246:668-669. ITOH N, TERACHIT, OHTAM, SEO M~ T h e Complete Amino Acid Sequence o f th e Sh o r te r Form of Huma n Basic Flbroblast Growth Factor Receptor Deduced f r o m Its CDNA. Blochem Biophys Res Commun 1990, 169:680~o85. JOLIVETM, IJSE I~ GRES-MASSEH, TARTAR& AUDmERT F, CHEDIDk Polyvalent Synthetic Vaccines: Relationship Between T Epitupes a n d Immunogenicity. Vaccine 1990, 8:35-40. JUSKEVICHJC, GUYERCG: Bovine Growth Hormone: Huma n Food Safety Evaluation. Science 1990, 249:875-883 KIMURAY, NAKANISHIK, MATSUNOI~ Enzymatic Synthesis o f the P r e c u r s o r o f Leu-enkephalin i n Waterimmiscible O r g a n ic Solvent Systems. Enzyme Mi6rob TeOSn0/1990, 12:272-280. KLUEPPELBERGUG, MOLEROX, BARRETTRW, MILLER LJ: Biochemical Characterization o f t h e Cholecystoklntn Receptor o n Chp212 H u m a n Neuroblastoma Cells. Mol Pharmaco11990, 38:159-163. KOESLSRJP, GODETIXCA, BOCKDJ, EPSTE~ RB: Synergistic Effects of Vinblastine a n d Recombinant Interferon- Beta o n Renal T u m o r Cell Lines. J Interferon Res 1990, 10:281-291. LEWISDE, ULRICHRG, ATASSIH, ATASSIMZ: HLA-DR Peptide Inhibits HIV-induced Syncytia. lmmunol Lett 1990, 24:127-131. LIM I, SPENCERS& MCKAYP, WATERSMJ: Regulation of Growth H o r m o n e (GH) Bloactivity by a Recombinant Hnman GH-Binding ProteIn. Endocrinology 1990, 127:1287-1291. LOWENADLERB, SVENNERHOLMAM, GIDLUNDM, HOLMGREN E, KEOOKK, SVANHOLMC, ULFFS, JOSEPHSONS: Enhanced I m m u n o g e n i c i t y o f Recombinant Peptide Pusimm Containing Multiple Copies o f a Heterologous T-Helper Epitope. Eur J Immunol 1990, 20:1541-1545. MACDOUGALLIC, IEWE NP, SAUNDERSMJ, COCHLINDL, DAVIESME, HOTIONRD, FOX KA& COLESGA, WILLIAMSJD: Long-term Cardiorespiratory Effects o f Amelioration o f Renal Anaemia by Erythropoietin. Lancet 1990, 335:489-492. MADISENl~ NEUBAUERM, PLOWMANG, ROSEND, SEGAPdN1 P, DASCHJ, THOMPSON&ZIMANJ, BENTZH, PURCHIO AF: Molecular Cloning o f a Novel Bone-forming Compound: Osteoinductive Factor. DNA 1990, 9:303-310. MOMPARLERP~ ONETTOPOTHIERN, MOMPAREERIF: Comparison o f Antineoplastic Activity o f Cytosine Aesbinoside and 5-Aza-2'Deoxycytidine A=o~ln~t H u ma n Leukemic Cells o f Different Phenotype. Leuk Res 1990, 14:755-760 NEMOTOY, YAMAMOTOT, TAKADAS, MATSUIY, OBINATA M: Antisense RNA o f th e Latent Feriod Gene (MerS) Inhibits th e Differentiation o f Murine E r y t h r o l e u k e m i a CeLls. Gene 1990, 91:261-265. NEMONAmSJ ETA&:Effect o f GM-CSF o n Circulating Granulocyte-monocyte Pr o g e n ito r s i n Autologous BMT [letter]. Lancet 1989, ll:1405-1407. NEMUNAnlSJ, SINGERJ~, BUCKNERCD, DURNAMD, EPSTEIN C, HILLP., STORBR, THOMASED, APPELBAUMFP~ Use o f Recombinant H u m a n Granulocyte-Macrophage Colony-Stimulating Factor i n Graft Failure after Bone Marrow Transplantation. Blood 1990, 76:24~253. NISHIKAWAS, N1SHIDAY, UEMURAH, YAMADAY, TANAKAT, UESUGIS, MORIKAWAM, UCHIDAE, HAYAKAWAT, IKEHARA

M: Structure a n d Activity o f Artificial Mutant Variants o f H u m a n Growth Hormone. Prot Eng 1989, 3:49-54. NIXONDF, HUETS, ROTHBARDJ, KIENYMP, DEI.CHAMBREM, THIRIARTC, RIZZAC~ GOTCHFM, MC~CHAELAJ: An HIV-1 a n d HIV-2 Cross-Reactive Cytotoxtc T-Cell Epitope. AIDS 1990, 4:841~845. OREFFO ROC, BONEWALDL, KUK1TA& GARRETFIR, SEYEDIN SM, ROSEND, MUNDYGPc I n h i b i t o r y Effects of t h e Bone-Derived Growth Factors Osteoinductive Factor a n d T r a n s f o r m i n g Growth Factor-Beta o n Isolated Osteoclasts. Endocrinology 1990, 126:3069-3075. PARDRIDGEWM, TRIGUEROD, BUCIAKJL ~-endorphtn Chimeric Peptides - - T r a n s p o r t T h r o u g h t h e Blood-brain B a r r i e r in V im a n d Cleavage o f Disulfide Linkage by Brain. Endocrinology 1990, 126:977-984. PmR GB, SMALLGJ, WARRENFIB: Protection Against Mucoid Pseudomonas-Aeruglnosa in Rodent Models o f E n d o b r o n c h l a l Infections. Science 1990, 249:537-540. PIGUETPF, COLLARTM& GRAUGE, SAPPINOA-P, VASSALD P: Re q u ir e me n t of T u m o o r Necrosis Factor for D e v e lo p me n t o f silica-induced Pu lmo n a ry Fibrosis. Nature 1990, 344:245-246. PINKJR1. SINIGAGLIAF: Characterizing T-cell Epitopes in Vaccine Candidates. Immunol Today 1989, 10:408-409. PLUDAJM, yARCHOANR, SMITHPD, MCATEEN, SHAYLE, OETFED, MAHAM, WAHLSM, MYERSCE, BRODER S: Subcutaneous Recombinant GranulocyteMacrophage Colony-stimulating Factor used as a Single Agent a n d i n an Alternating Regimen w i t h Azldothymidine i n Leukopenic Patients w i t h Severe H u ma n Immunodeficiency Virus Infection. Blood 1990, 76:463-472. RAWLINSONI, DALTONBJ, ROGERSK, REESRC: T h e Influence o f I n t e r f e r o n M p h a a n d G~tmma, Singly o r i n Combination o n H u ma n Natural Cell Mediated Cytotoxicity. Biosci Rep 1989, 9:549-558. RAYJ, OKAMORAH, KELLYP& COOKENE, LIEBHABERSA: H u ma n G r o w t h Hormone-variant Demonstrates a r e c e p t o r Bin d in g Profile Distinct from that o f Normal Pituitary Growth Hormone. J Biol CJ~m 1990, 265:793~7944. RUDMAND, FELLERAG, NAGRAJHS, GERGANSG& LAUTHA PY, GOLDBERGAF, SCHLENKERP~ COHN ~ RUDMANl~7, MATYSONDE: Effects o f H u m a n Growth H o rm o n e in Men Over 60 Years Old. N EnglJ Med 1990, 323:1~. SALOMONF, CUNEORC, HESP IL SONKSENPH: T h e Effects of T r e a t m e n t w i t h Recombinant H u m a n Growth H o r m o n e o n Body Composition and Metabolism in Adults w i t h Growth H o r m o n e Deficiency. N EnglJ Med 1989, 321:1797 1803. SATOK, HOTFAM, KAGEYAMAJ, HU H-Y, DONGM-H, LINGN: Synthetic Analogs o f Growth Hormone-releasing Factor w i t h Antagonistic Activity in V~ro~ Biochem B~Ohys Res Commun 1990, 167:360-366. SATOM, SARDANAMK, GRASSERW& GAP,SKYVM, MURRAY JM, GOULDRJ: Echtstatin is a Potent I n h i b i t o r of Bone Resorption in Culture. J Cell Bio11990, 111:1713-1723. SCHATFENBERGA ETA&:Allogeneic Bone Marrow T r a n s p la n ta tio n f o r Leukemia w i t h Marrow Grafts Depleted o f Lymphocytes by Counterllow Centrifngatton. Blood 1990, 75:1356~1363. SOU~ KF, CHOUT C, FOXJJ, WATANABEKA. GI/DFFC• I n h i b t i o n o f Simian Varicella Virus Infection of Monkeys by l-(20Deoxy-2-Fluoro-l-~-DArabinofuranosyl)-5-Ethyluracll (FEAU) a n d Synergistic Effects o f Combination w i t h H u m a n Recombinant inteferon-~. Ant~iral Res 1990, 13:165-174. STRAWICHE, GLIMCHERMJ: T o o th I~n~melins Identified Mainly as Serum Proteins - Major Enamelin is Albumin. EurJBiochem 1990, 191:47 56. TAMJP, CLAVUOP, LUY & NUSSENZWEIGV, NUSSENZWEEIGP~ ZAVALAF: i n c o r p o r a t i o n of T a n d B Epitopes o f t h e Cirumsporozoite Pr o te in i n a Chemically Defined Synthetic Vaccine Against Malaria. J Exp Med 1990, 171:299-306. TAMURAS, FUNATOH, HIRABAYASHIY, KIKUTAK, SUZU1G Y, NAGAMI T, AIZAWAC, NAKAGAWAM, KURATA T: Functional Role o f Respiratory Tract Haemagglutinin-Specillc IgA Antibodies i n Protection A ~ t n s t Influenza. Vaccine 1990, 8:479-485. TANIF, llo K, CHIBAH, YOSHIKAWAM: Isolation a n d Characterization o f Opioid Antagonist Peptides Derived f r o m H o m a n Lactoferrin. Agm Biol Chem 1990, 54:1803~1810. TASTEMAINC: Grafting Ovarian Cells to Combat Sterility ( i n F r e n c h ) . Recherche 1990, 21:1104-1105.

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Pharmaceutical applications Miscellaneous USU1N, MIMNAUGHEG, SINHABK: Synergistic Antttumor Activity o f Etoposide a nd Huma n Interleukinla~Against H um a n Melanoma Cells. J Natl Cancer lint 1989, 81:1904-1909. WAGNERJE, SANTOSGW, NOGASJ, ROWLEYSO, DAVISJ, VOGELSANGGB, FARMERElL ZEHNBAOERB& SARALIL DONNENBERGAn: Bone M a r r o w Graft E n g i n e e r i n g by Counterflow Centrifugal Elutriatinn - Results o f a Phase-I-I1 Clinical Trial. Blood 1990, 75:1370-1377.

WANGEA, ROSENV, D'ALESSANDROJS, BAUDUYM, COP,DES P, HARADAT, ISRAELDI, HEWICKRM, KERNSKM, LAPANp, LU'2~NBERGDP, MCQUAIDD, MOUTSATSOS 1K, NOVE J, WOZNEYJM: Recombinant H u m a n Bone Morphogenetic Pr o te in induces Bone Formation. Proc Natl A c a d Sci U S A 1990, 87:2220-2224. WEEDLERM, COTFERTG: Biochemical Characterization Studies o n a Leukocyte Alloantigen Expressed

w i t h High Frequency in Leukaemia Patients. Leuk Res 1990, 14:761-770. WORLDHEALTHORGANISA~ONTASKFORCEON METHODSFOR THE REGULATIONOF MALEFEF(flLITY:Contraceptive Efficacy o f Testosterone-induced Azoospermia i n Normal Men. Lancet 1990, 336:955~959.